Table 1.
Association of A3AB deletion with bladder cancer risk in individuals of European ancestry, a Japanese population, and the combined set
| Deletion genotype |
European ancestry 1,719 cases and 2,566 controls |
Japanese 1,116 cases and 945 controls |
Meta-analysis 2,835 cases and 3,511 controls |
Heterogeneity | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases, N (%) |
Controls, N (%) |
OR (CI)* |
P-val* | Cases, N (%) |
Controls, N (%) |
OR (CI) | P-val | OR (CI) | P-val | P-val | |
| I/I | 1,531 (89.06) | 2,221 (86.55) | ref | - | 622 (55.73) | 495 (52.38) |
Ref | - | ref | - | - |
| I/D or D/D | 188 (10.94) | 345 (13.45) | 0.78 | 0.044 | 494 (44.27) |
450 (47.62) |
0.87 (0.73 – 1.04) | 0.128 | 0.85 (0.74 – 0.97) | 0.013 | 0.66 |
A3AB deletion alleles: I - insertion, D –deletion; A3AB deletion genotypes: deletion absence (I/I) vs. deletion presence (I/D or D/D);
*
ORs and p-values are adjusted for age, sex, smoking status, and study site (SBCS, Spain and PLCO, USA). Ref. – reference group.