Table 2.
Top scoring genes and percentage inclusion in S1500+ by characteristic.
| Characteristic | Genes with highest summary score | Percentage of genes appearing on S1500+ |
|---|---|---|
| Angiogenesis | VEGFA, THBS1, HIF1A, MMP2, TWIST1 | 30.3% |
| Apoptosis | PTRH2, CAV1, MMP11, SRC, TP53 | 75.8% |
| Cell cycle | CCNB1, CDK1, CDK2, CDK4, CCNA1 | 69.7% |
| Epigenetics | GREB1, HMGCS2, TFF3, TSSC4, JUNB | 21.2% |
| Genotoxicity | EXO1, ATM, XRCC5, RAD51, BRIP1 | 39.4% |
| Growth hormones | IGF1, GH2, GH1, GHR, CSH2 | 30.3% |
| Immortalization | BCL2L1, BCL2, ZNF165, ARMC1, BIRC5 | 30.3% |
| Immunomodulation | IL2, CD69, GATA3, CD38, CSF1 | 48.5% |
| Inflammation | IL6, PYCARD, IL1B, F3, IL8 | 54.5% |
| Mammary | BRCA2, BRCA1, PRLR, PRL, ERBB2 | 39.4% |
| Oxidative stress | NOL3, HMOX1, CAT, ENO1, HSPA8 | 42.4% |
| Proliferation | NOTCH1, MYC, CTNNB1, TBX3, CCND2 | 36.7% |
| Steroid hormones | ESR1, ESR2, PGR, CYP17A1, STS | 51.5% |
| Xenobiotic metabolism | NR1I3, NR1I2, EPHX1, NAT1, CYP1A2 | 81.8% |