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. 2019 Apr 8;76(7):866–867. doi: 10.1001/jamaneurol.2019.0522

Table. Confirmed Cases of Enterovirus-Associated Fulminant Hepatitis in Association With Anti-CD20 Agents.

Source, Year Anti-CD20 Agent Patient, No. Indication for Anti-CD20 Agent Enterovirus-Associated Disease
Clinical Presentation Type of Enterovirus Identified Diagnosis Treatment for Enteroviral Infection Outcome
Lefterova et al,1 2013 Rituximab 1 B-cell non-Hodgkin lymphoma Meningo-encephalitis and fulminant hepatitis Echovirus 18 Real-time polymerase chain reaction in cerebrospinal fluid, plasma, and liver tissue Plasmapheresis Death
Morgan et al,2 2015 Rituximab 1 Follicular lymphoma Fulminant hepatitis Echovirus 9 Real-time polymerase chain reaction in plasma and liver tissue Intravenous IgG Recovery with sequelae (memory loss and fatigue)
Bajema et al,3 2017 Rituximab 1 Nephrotic syndrome with minimal change disease Meningo-encephalitis and fulminant hepatitis Echovirus 9 Real-time polymerase chain reaction in plasma and liver tissue None Death