Table 2. Univariate and Multivariate Logistic Regression Analyses of Potential Risk Factors and the Association With Loss to Follow-up Among Patients With Neovascular Age-Related Macular Degeneration Who Received Intravitreal Anti–Vascular Endothelial Growth Factor Injections.
Variable | Lost to Follow-up, No. (%) | Univariate Model | Multivariate Modela | ||
---|---|---|---|---|---|
Odds Ratio (95% CI) | P Value | Odds Ratio (95% CI) | P Value | ||
Age, y | |||||
≤80 | 583 (15.8) | 1 [Reference] | 1 [Reference] | ||
81-85 | 458 (21.1) | 1.42 (1.24-1.63) | <.001 | 1.58 (1.38-1.82) | <.001 |
86-90 | 567 (27.8) | 2.05 (1.80-2.33) | <.001 | 2.29 (2.00-2.62) | <.001 |
>90 | 395 (35.7) | 2.95 (2.54-3.44) | <.001 | 3.31 (2.83-3.86) | <.001 |
Sex | |||||
Male | 679 (22.0) | 1 [Reference] | |||
Female | 1324 (22.4) | 1.02 (0.92-1.14) | .66 | ND | ND |
Race/ethnicity | |||||
White | 1606 (20.3) | 1 [Reference] | 1 [Reference] | ||
African American | 39 (27.3) | 1.47 (1.01-2.13) | .04 | 1.47 (1.00-2.16) | .05 |
Asian | 34 (33.7) | 1.99 (1.31-3.02) | .001 | 2.63 (1.71-4.03) | <.001 |
Otherb | 11 (42.3) | 2.88 (1.32-6.27) | .008 | 3.07 (1.38-6.82) | .006 |
Unreported | 313 (37.6) | 2.37 (2.04-2.75) | <.001 | 2.29 (1.96-2.68) | <.001 |
Regional average AGI, $ | |||||
>100 000 | 362 (18.4) | 1 [Reference] | 1 [Reference] | ||
76 000-100 000 | 392 (21.7) | 1.23 (1.05-1.44) | .01 | 1.28 (1.08-1.50) | .004 |
51 000-75 000 | 765 (22.8) | 1.32 (1.14-1.51) | <.001 | 1.35 (1.17-1.56) | <.001 |
≤50 000 | 484 (25.8) | 1.55 (1.33-1.81) | <.001 | 1.52 (1.30-1.79) | <.001 |
Distance, miles | |||||
≤10 | 1355 (21.7) | 1 [Reference] | 1 [Reference] | ||
11-20 | 374 (21.6) | 1.00 (0.88-1.14) | .97 | 1.05 (0.91-1.20) | .51 |
21-30 | 103 (25.1) | 1.21 (0.96-1.53) | .10 | 1.33 (1.05-1.69) | .02 |
>30 | 171 (27.5) | 1.37 (1.14-1.65) | .001 | 1.55 (1.28-1.88) | <.001 |
Eye involvement | |||||
Bilateral | 518 (18.0) | 1 [Reference] | 1 [Reference] | ||
Unilateral | 1485 (24.2) | 1.45 (1.30-1.62) | <.001 | 1.44 (1.28-1.61) | <.001 |
Abbreviation: AGI, adjusted gross income (rounded to the nearest $1000); ND, no data.
Multivariate analysis adjusted for age, race/ethnicity, regional average AGI, distance, and eye involvement.
Other includes Hispanic, Native American, and Pacific Islander.