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Ribbon depiction of human MTERF1 (PDB ID: 3MVA) in purple bound to the tRNALeu termination sequence. DNA coloring as in Figure 2. A schematic depiction of MTERF1 domains is shown below. MTS: Mitochondrial targeting sequence. MTERF1 binds to a specific site in the mitochondrial genome and flips out multiple bases from the double stranded DNA. This binding is thought to act as a roadblock for the transcribing RNA polymerase, thus causing transcription termination.
