FIG A2.

Details of the BRAF rearrangements, RAF1 rearrangements, and BRAF short variant mutations. The diagram illustrates BRAF (top) and RAF1 (bottom) rearrangements, including fusions, N-terminal deletions, and kinase domain duplications. Exons are numbered. For fusion, exons (e) are annotated with the last exon included in the 5′ partner and the first exon included in the 3′ partner. In addition, BRAF rearrangements at intron 9 (n = 6) and intron 7 (n = 1) and RAF1 rearrangement at intron 7 with no clear fusion partner were identified (data not shown). The table lists the 43 BRAF mutations identified.