Table 2.
Experimental Measures of Stability and Well-Foldednessa
| parent:edit | fa | φ222 (mdeg dmol−1 cm−2) | ΔH (kj/mol) | Tm (°C) | PK50 (μg) |
|---|---|---|---|---|---|
| D16:22:Δe45–53 | 0.36 ± 0.03 | 17.0 ± 0.9 | 164 ± 40 | 62.9 ± 0.9 | 1.8 ± 0.8 |
| D16:22: Δe46–54 | 0.93 ± 0.01 | 32.4 ± 0.5 | 565 ± 95 | 68.5 ± 0.6 | 9.5 ± 2.4 |
| D16:22: Δe47–55 | 0.80 ± 0.03 | 28.7 ± 0.6 | 220 ± 23 | 62.7 ± 0.6 | 1.5 ± 0.1 |
| D16:24: Δe45–53 | 0.49 ± 0.08 | 19.4 ± 2.0 | 215 ± 14 | 62.8 ± 0.4 | 0.4 ± 0.2 |
| D16:24: Δe46–54 | 0.88 ± 0.04 | 30.5 ± 1.5 | 624 ± 63 | 64.6 ± 0.3 | 3.6 ± 0.5 |
| D16:24: Δe47–55 | 0.72 ± 0.04 | 25.8 ± 1.1 | 194 ± 10 | 61.6 ± 0.5 | 1.0 ± 0.2 |
a
Error ranges are given as one standard deviation.