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. Author manuscript; available in PMC: 2020 Feb 14.
Published in final edited form as: J Med Chem. 2019 Feb 5;62(3):1643–1656. doi: 10.1021/acs.jmedchem.8b01958

Figure 3.

Figure 3.

DO130 (7) does not show time-dependent inhibition of ABHD12. (A) Comparison of ABHD12 inhibitory activities of JJH350 (3) and DO130 (7) as measured by gel-based ABPP with membrane lysate of ABHD12-transfected HEK293T cells using an FP-Rh probe (1 μM, 45 min, 37 °C). A representative gel is shown. (B) Bar graph representation of ABHD12 band intensity obtained in (A). N = 3. The data represent the mean ± SD.