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. Author manuscript; available in PMC: 2020 Feb 14.
Published in final edited form as: J Med Chem. 2019 Feb 5;62(3):1643–1656. doi: 10.1021/acs.jmedchem.8b01958

Scheme 1. Synthesis of 1–3a.

Scheme 1.

aReagents and conditions: (a) 4-phenoxybenzaldehyde, acetic acid, NaBH(OAc)3, dry THF, rt, 45% (ref 20); (b) 4-phenoxybenzoic acid, EDCI, HOBt·H2O, iPr2NEt3, rt, 74% for 2, 86% for 3.