Table 1. Relationship between serum MMP-9 level and clinicopathological features of HC patients (n, %).
| Item | n | MMP-9 (ng/mL) | p | ||
|---|---|---|---|---|---|
| <201.93 (n=75) | ≥201.93 (n=106) | ||||
| Age | <60 years | 97 | 38(50.7%) | 59(55.7%) | 0.507 |
| ≥60 years | 84 | 37(49.3%) | 47(44.3%) | ||
| Sex | Male | 103 | 42(56.0%) | 61(57.6%) | 0.836 |
| Female | 78 | 33(44.0%) | 45(42.4%) | ||
| Tumor size | <2.5 cm | 113 | 51(68.0%) | 62(58.5%) | 0.193 |
| ≥2.5 cm | 68 | 24(32.0%) | 44(41.5%) | ||
| Differentiation | High and moderate | 174 | 72(96.0%) | 102(96.2%) | 0.754 |
| Poor | 7 | 3(4.0%) | 4(3.8%) | ||
| Bismuth-Corlette classification | I+II | 42 | 26(34.7%) | 16(15.1%) | 0.002 |
| IIIa+IIIb+IV | 139 | 49(65.3%) | 90(84.9%) | ||
| Lymph node metastasis | Negative | 117 | 58(77.3%) | 59(55.7%) | 0.003 |
| Positive | 64 | 17(22.7%) | 47(44.3%) | ||
| Nerve invasion | Negative | 109 | 49(65.3%) | 60(56.6%) | 0.237 |
| Positive | 72 | 26(34.7%) | 46(43.4%) | ||
| Portal vein invasion | Negative | 126 | 58(77.3%) | 68(64.2%) | 0.057 |
| Positive | 55 | 17(22.7%) | 38(35.8%) | ||
| Hepatic artery invasion | Negative | 142 | 56(74.7%) | 86(81.1%) | 0.297 |
| Positive | 39 | 19(25.3%) | 20(18.9%) | ||
| Liver invasion | Negative | 132 | 56(74.7%) | 76(71.7%) | 0.658 |
| Positive | 49 | 19(25.3%) | 30(28.3%) | ||
| Incised margin | Negative(R0) | 151 | 66(88.0%) | 85(80.2%) | 0.164 |
| Positive(R1) | 30 | 9(12.0%) | 21(19.8%) | ||
| Total bilirubin | <100 mg/L | 77 | 35(46.7%) | 42(39.6%) | 0.345 |
| ≥100 mg/L | 104 | 40(53.3%) | 64(60.4%) | ||
| Preoperative biliary drainage | Undone | 126 | 54(72.0%) | 72(67.9%) | 0.557 |
| Done | 55 | 21(28.0%) | 34(32.1%) | ||
| Postoperative radiotherapy | Undone | 109 | 47(62.7%) | 62(54.5%) | 0.572 |
| Done | 72 | 28(37.3%) | 44(41.5%) | ||