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. 2019 Jun 19;14(6):e0218272. doi: 10.1371/journal.pone.0218272

Fig 1. Increased C3bBbP levels in supernatants from AAV PMN.

Fig 1

C3bBbP (stable alternative pathway C3 convertase, a sign of alternative pathway activation) formed in normal serum after incubation with supernatants from AAV PMN (neutrophils from vasculitis patients) or HC PMN (neutrophils from healthy controls), that have been primed with TNF-α and then stimulated with ANCA IgG (immunoglobulin G fraction from PR3-ANCA positive patients). Mean and SEM are shown. N = 50 AAV PMN samples (5 PMN donors, 10 different ANCA IgG stimuli) and 50 HC PMN samples (5 PMN donors, 10 different ANCA IgG stimuli). Statistical analysis: Mann Whitney, p = 0.01.