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. Author manuscript; available in PMC: 2019 Jun 19.
Published in final edited form as: Biochemistry. 2018 Aug 27;57(39):5748–5758. doi: 10.1021/acs.biochem.8b00577

Figure 1.

Figure 1.

Tunnels into the vorapaxar binding site of PAR1. (A) Extracellular ribbon view of the PAR1–vorapaxar crystal structure (Protein Data Bank entry 3VW7) with ECL2 colored green, ECL3 colored orange, and vorapaxar rendered as spheres. TMs are labeled 1 –7. The TM4–TM5 tunnel is labeled by a single arrowhead, and the TM6–TM7 tunnel is labeled by a double arrowhead. (B) Extracellular surface rendering. (C) Surface rendering of the TM6–TM7 tunnel as seen from the plane of the plasma membrane, rotated 90° from the extracellular view. (D) Surface rendering of the TM4–TM5 tunnel as seen from the plane of the plasma membrane, rotated 115° from the view in panel C. The approximate plane of the POPC headgroups in the outer leaflet of the lipid bilayer is indicated by the dashed line.