Table 3.
Target | Pathogen | Phenotype | Ref. |
---|---|---|---|
T cells | HIV | Target cell killing by NK cells differentiated from iPSCs | 77,78 |
Monocytes | HIV | Introduction of CCR5del32 mutation causes HIV resistance | 79 |
Neurons | HSV-1 | Neurons derived from iPSCs from patients with TLR3 or UNC-93B mutations show increased susceptibility | 80 |
Neural organoids | Zika | Impaired organoid growth, decreased ventricular zone thickness, increased ventricle size, decreased cortical folding | 31,33,37,76,82–86 |
Gastric organoids | Helicobacter pylori | Increased epithelial cell proliferation | 30 |
Intestinal organoids | Clostridium difficile | Impaired epithelial barrier function | 90 |
Intestinal organoids | Salmonella | Epithelial cell invasion | 91 |
iPSCs, induced pluripotent stem cells; NK, natural killer.