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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Nat Rev Genet. 2019 Jul;20(7):377–388. doi: 10.1038/s41576-019-0100-z

Table 3.

Key studies modelling infectious disease using human iPSCs.

Target Pathogen Phenotype Ref.
T cells HIV Target cell killing by NK cells differentiated from iPSCs 77,78
Monocytes HIV Introduction of CCR5del32 mutation causes HIV resistance 79
Neurons HSV-1 Neurons derived from iPSCs from patients with TLR3 or UNC-93B mutations show increased susceptibility 80
Neural organoids Zika Impaired organoid growth, decreased ventricular zone thickness, increased ventricle size, decreased cortical folding 31,33,37,76,82–86
Gastric organoids Helicobacter pylori Increased epithelial cell proliferation 30
Intestinal organoids Clostridium difficile Impaired epithelial barrier function 90
Intestinal organoids Salmonella Epithelial cell invasion 91

iPSCs, induced pluripotent stem cells; NK, natural killer.