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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: J Mol Med (Berl). 2019 May 17;97(7):1033–1047. doi: 10.1007/s00109-019-01791-z

Figure 5.

Figure 5.

A. Speckle-tracking based strain analysis in D166V (top panel) and WT (bottom panel) ~1 month post AAV/PBS delivery. Global longitudinal strain (GLS); Ejection Fractionstr; Fractional Shorteningstr; Cardiac Outputstr, Stroke Volumestr; EDVstr, End Diastolic Volume-strain. Data are mean ± SEM. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001, by Student’s t-test. B. Representative three-dimensional longitudinal strain deformation images for D166V AAV/PBS (top panel) vs WT AAV/PBS (bottom panel) showing contraction (red, positive) and relaxation (blue, negative) over six LV segments during four consecutive cardiac cycles. The orange line has been added to aid comparison of the images’ scale. Note significant improvement for strain parameters in D166V AAV animals compared to PBS. WT animals showed no significant differences.