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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Psychol Med. 2018 Dec 19;49(16):2745–2753. doi: 10.1017/S003329171800377X

Fig. 1.

Fig. 1.

A Common Pathway Model Depicting the Genetic and Environmental Relationship between ‘Broadly Defined Depression’ and measures of life-time major depression (MD), self-report depressive symptoms (DS) and self-report Neuroticism (SN). Capital ‘A’ and ‘E’ reflect additive genetic and unique environmental effects, respectively. The subscript ‘C’ reflects the common factor and ‘S’ the phenotype specific effects. So EC refers to the unique environmental effect for the negative affect common factor while ASMD refers to the genetic effect specific to MD. Lower-case ‘a’ and ‘e’ refer to the path coefficients (standardized regression coefficients) that reflect genetic and unique environmental effects. The lambda paths (λ) reflect the loadings of major depression, self-report DS and SN on the common factor of negative affect.