. 2019 Apr 2;104(8):3265–3278. doi: 10.1210/jc.2019-00129

Table 3.

Change in Clinical Variables With Treatment From Baseline to Study End (3 mo)

	Placebo (N = 16)	Metformin (N = 19)	Unadjusted P Value	Adjusted P Value
Change in weight, kg	1.1 ± 1.8	−0.7 ± 2.6	0.025^a	0.030^a
Change in FFM, kg	1.3 ± 2.2	0.13 ± 1.2	0.085	0.386
Change in BMI percentile	0.09 ± 0.88	−0.20 ± 0.88	0.343	0.252
Change in BMI z score	0.02 ± 0.08	−0.04 ± 0.10	0.082	0.041^a
Change in waist circumference, cm	−0.31 ± 7.2	−1.03 ± 6.6	0.775	0.860
Change in HbA1c, %	0.37 ± 0.59	0.15 ± 1.24	0.512	0.562
Change in HbA1c, mol/mmol	2.9 ± 4.1	1.4 ± 11.2
Change in TDI/kg	−0.05 ± 0.16	−0.06 ± 0.32	0.934	0.917

Data are shown as mean ± SD. Data are adjusted for baseline values, sex, and random center effects.

^{^a}

P < 0.05–0.01.