Table 2.
eGFR values in diabetic patients from the five study cohorts
| Study cohort | eGFR (mL/min/1.73 m2) according to
IRS1 G92R genotype |
β value (P value) | ||
|---|---|---|---|---|
| GG | GR | RR | ||
| SGR 1 (N) | 842 | 137 | 7 | −1.41 (0.430) |
| 75.7 ± 21.0 | 74.3 ± 22.9 | 72.4 ± 16.9 | ||
| SGR 2 (N) | 565 | 74 | 2 | −0.085 (0.979) |
| 94.1 ± 26.8 | 93.0 ± 28.9 | 111.5 ± 26.2 | ||
| Foggia (N) | 539 | 78 | 5 | −6.71 (0.058) |
| 87.0 ± 33.0 | 81.3 ± 30.6 | 65.7 ± 20.9 | ||
| Pisa (N) | 797 | 144 | 1 | −1.18 (0.489) |
| 83.7 ± 19.2 | 82.7 ± 19.9 | 68.6 | ||
| Boston (N) | 694 | 87 | 2 | −0.02 (0.993) |
| 70.2 ± 21.7 | 69.9 ± 20.7 | 76.8 ± 5.6 | ||
| All samples (N) | 3436 | 520 | 17 | −1.82 (0.086)a |
| 81.2 ± 25.3 | 79.6 ± 24.8 | 75.3 ± 21.5 | ||
Data are expressed as number of patients (N) and mean ± SD. eGFR, estimated glomerular filtration rate as calculated according to MDRD equation. β values are expressed as mL/min/1.73 m2.
SGR1, first cohort from San Giovanni Rotondo; SGR2, second cohort from San Giovanni Rotondo; GG, patients homozygous for the G allele; GR, heterozygous patients; RR, patients homozygous for the R allele.
aAdjusted for ‘study sample’.