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. 2019 Mar 7;65(3):267–273. doi: 10.1262/jrd.2018-156

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This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)

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Fig. 1. — Poor second ovarian stimulation by hFSH in some female monkeys. A: Schematic overview of ovarian stimulation in a cynomolgus monkey. Day 0 is the start date of hFSH administration. Shown below is the timing of blood sampling. The second ovarian stimulation was performed after at least 6 months in consideration of animal welfare. OPU; ovum pick up. B and C: Laparoscopic observation of ovaries during the first (B) and second (C) treatment by hFSH. Arrows indicate translucent growing follicles. CE2137F, and CE2000F are identification codes for each cynomolgus monkey. N.D., Not determined.