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. 2019 Mar 7;65(3):267–273. doi: 10.1262/jrd.2018-156

Fig. 3.

Fig. 3.

Production of antibodies against hFSH is associated with poor second ovarian response. A: Detection of antibodies against hFSH in serum. Because the level of antibodies against hFSH from first to second GnRH administrations was 1 ± 0.46, we considered that the antibody level was elevated significantly when the level of antibodies against hFSH exceeded 1.46. Red and black lines indicate Ab (+) and Ab (–), respectively. B: Numbers of total oocytes collected from cynomolgus monkeys without or with the antibody production. C: Percentages of MII oocytes collected from cynomolgus monkeys without or with the antibody production. D: Percentages of GV, MI, MII, and DG oocytes collected from cynomolgus monkeys without or with the antibody production at the second superovulation. n.s; not significant.