Table 1.

Limitations of Hematopoietic Stem Cell Transplantation by Donor Type

Type of Donor	Limitations
HLA-matched sibling	Paucity of fully matched donors
Matched unrelated donor	Paucity of donors
	Increased risk of GVHD
Haploidentical donor	Increased risk of graft rejection and GVHD
Umbilical cord blood from	Paucity of donors
sibling or unrelated donor	Limited use for young adults
	High rate of nonengraftment in unrelated umbilical cord blood transplants
	Utility limited by the recipients’ body weight

GVHD, graft-vs-host disease; HLA, human leukocyte antigen.