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. 2019 Summer;19(2):116–122. doi: 10.31486/toj.18.0138

Table 2.

Specific Pathogens and Antibiotic Treatment of Acute Osteomyelitis in Children

Organism	Treatment	Alternatives
Methicillin-susceptible Staphylococcus aureus	Antistaphylococcal penicillins^a	Cefazolin, clindamycin
Methicillin-resistant Staphylococcus aureus	Clindamycin,^b vancomycin	Linezolid, daptomycin, trimethoprim-sulfamethoxazole
Group A Streptococcus	Penicillin G, ampicillin, amoxicillin	Clindamycin^b
Streptococcus pneumoniae	Ceftriaxone,^b clindamycin^b	Vancomycin
	Penicillin G^b
	Ampicillin, amoxicillin^b
Kingella kingae	Ampicillin or ampicillin-sulbactam
	Cephalosporin
Enteric gram-negative rods	Ceftriaxone	Ciprofloxacin
Pseudomonas aeruginosa	Ceftazidime, ticarcillin-clavulanate	Ciprofloxacin
Neisseria gonorrhoeae	Ceftriaxone	Penicillin G^b
Salmonella spp	Ceftriaxone	Ampicillin^b
Anaerobes	Penicillin, clindamycin	Metronidazole, meropenem

^aOxacillin, nafcillin, cloxacillin, flucloxacillin, dicloxacillin.

^bFor susceptible strains.