Fig. 1.

Distribution of individual exposure ratio (IER) [area under the curve new/area under the curve old] obtained with baseline-adjusted T4 (left panel), and unadjusted T4 (right panel) plasma concentrations. Blue vertical straight lines are the acceptable pre-defined limits, namely 0.9 and 1.11. An individual with an IER within these limits has an observed variation of exposure of less than 10% when switching from the old to the new formulation. Red dotted vertical straight lines, 0.8 and 1.25, are respectively, the limits below and above which the variation of exposure is greater than 20% when switching from the old to the new formulation