Table 1. Data on Women With FIGO Stage I or II Endometrial Cancer Who Had Surgery Before (Group 1) or After (Group 2) Introduction of MIRS.
| Characteristic | Women, No. (%) | P Valuea | Women, No. (%) | P Valuea | Women, No. (%) | P Valuea | |||
|---|---|---|---|---|---|---|---|---|---|
| MIS Group 1 (n = 436) | MIS Group 2 (n = 1851) | TAH Group 1 (n = 2655) | TAH Group 2 (n = 712) | Overall Group 1 (n = 3091) | Overall Group 2 (n = 2563) | ||||
| Age | |||||||||
| ≤59 y | 118 (27.1) | 441 (23.8) | .06 | 641 (24.1) | 145 (20.4) | .004 | 759 (24.6) | 586 (22.9) | .03 |
| 60-66 y | 123 (28.2) | 451 (24.4) | 692 (26.1) | 166 (23.3) | 815 (26.4) | 617 (24.1) | |||
| 67-74 y | 111 (25.5) | 521 (28.2) | 648 (24.4) | 175 (24.6) | 759 (24.6) | 696 (27.2) | |||
| ≥75 y | 84 (19.3) | 438 (23.7) | 674 (25.4) | 226 (31.7) | 758 (24.5) | 664 (25.9) | |||
| BMI | |||||||||
| <25.0 | 152 (35.7) | 539 (30.6) | .23 | 891 (34.4) | 245 (35.3) | .72 | 1043 (34.5) | 784 (31.9) | .004 |
| 25.0-29.9 | 112 (26.3) | 494 (28.0) | 801 (30.9) | 217 (31.2) | 913 (30.2) | 711 (28.9) | |||
| 30.0-34.9 | 78 (18.3) | 361 (20.5) | 501 (19.3) | 121 (17.4) | 579 (19.2) | 482 (19.6) | |||
| ≥35.0 | 84 (19.7) | 370 (21.0) | 401 (15.5) | 112 (16.1) | 485 (16.1) | 482 (19.6) | |||
| Unknown, No. | 10 | 87 | 61 | 17 | 71 | 104 | |||
| CCI | |||||||||
| 0 | 293 (67.2) | 1220 (65.9) | .18 | 1769 (66.6) | 442 (62.1) | .08 | 2062 (66.7) | 1662 (64.9) | .09 |
| 1 | 89 (20.4) | 340 (18.4) | 399 (15.0) | 121 (17.0) | 488 (15.8) | 461 (18.0) | |||
| ≥2 | 54 (12.4) | 291 (15.7) | 487 (18.3) | 149 (20.9) | 541 (17.5) | 440 (17.2) | |||
| ASA class | |||||||||
| I | 201 (46.4) | 587 (32.2) | <.001 | 1007 (38.0) | 196 (27.7) | <.001 | 1208 (39.2) | 783 (30.9) | <.001 |
| II | 207 (47.8) | 1041 (57.1) | 1376 (51.9) | 407 (57.5) | 1583 (51.3) | 1448 (57.2) | |||
| ≥III | 25 (5.8) | 196 (10.8) | 269 (10.1) | 105 (14.8) | 294 (9.5) | 301 (11.9) | |||
| Unknown, No. | 3 | 27 | 3 | 4 | 6 | 31 | |||
| Smoking status | |||||||||
| Never | 296 (71.0) | 1115 (67.6) | .003 | 1381 (63.8) | 392 (62.7) | .001 | 1677 (65.0) | 1507 (66.2) | <.001 |
| Former | 55 (13.2) | 329 (19.9) | 366 (16.9) | 140 (22.4) | 421 (16.3) | 469 (20.6) | |||
| Active | 66 (15.8) | 206 (12.5) | 417 (19.3) | 93 (14.9) | 483 (18.7) | 299 (13.1) | |||
| Unknown, No. | 19 | 201 | 491 | 87 | 510 | 288 | |||
| Tumor riskb | |||||||||
| Low | 280 (65.4) | 1126 (62.3) | .007 | 1362 (52.4) | 319 (45.3) | <.001 | 1642 (54.2) | 1445 (57.6) | .001 |
| Intermediate | 93 (21.7) | 335 (18.5) | 623 (24.0) | 148 (21.0) | 716 (23.7) | 483 (19.2) | |||
| High | 55 (12.9) | 346 (19.2) | 615 (23.7) | 237 (33.7) | 670 (22.1) | 583 (23.2) | |||
| Unknown, No. | 8 | 44 | 55 | 8 | 63 | 52 | |||
| Intra-abdominal adhesion | |||||||||
| No | 372 (85.7) | 1169 (64.2) | <.001 | 2034 (76.6) | 462 (65.1) | <.001 | 2406 (77.9) | 1631 (64.4) | <.001 |
| Yes | 62 (14.3) | 652 (35.8) | 620 (23.4) | 248 (34.9) | 682 (22.1) | 900 (35.6) | |||
| Unknown, No. | 2 | 30 | 1 | 2 | 3 | 32 | |||
| Lymphadenectomy | |||||||||
| No | 311 (71.3) | 1222 (67.1) | .09 | 1995 (75.4) | 400 (58.1) | <.001 | 2306 (74.8) | 1662 (64.6) | <.001 |
| Yes | 125 (28.7) | 599 (32.9) | 651 (24.6) | 289 (41.9) | 776 (25.2) | 888 (35.4) | |||
| Unknown, No. | 0 | 30 | 9 | 23 | 9 | 53 | |||
| Socioeconomic class | |||||||||
| High | 56 (12.8) | 293 (15.8) | .50 | 320 (12.1) | 99 (13.9) | <.001 | 376 (12.2) | 392 (15.3) | .001 |
| Intermediate-high | 86 (19.7) | 323 (17.5) | 399 (13.0) | 129 (18.1) | 485 (15.7) | 452 (17.6) | |||
| Intermediate | 93 (21.3) | 399 (21.6) | 546 (20.6) | 169 (23.7) | 639 (20.7) | 568 (22.2) | |||
| Intermediate-low | 122 (28.0) | 494 (26.7) | 771 (29.0) | 202 (28.4) | 893 (28.9) | 696 (27.2) | |||
| Low | 79 (18.1) | 342 (18.5) | 619 (23.3) | 113 (15.9) | 698 (22.6) | 455 (17.8) | |||
| Treatment at cancer center | |||||||||
| No | 44 (10.1) | 10 (0.5) | <.001 | 1276 (48.1) | 91 (12.8) | <.001 | 1320 (42.7) | 101 (3.9) | <.001 |
| Yes | 392 (89.9) | 1841 (99.5) | 1378 (51.9) | 621 (87.2) | 1770 (57.3) | 2462 (96.1) | |||
| Unknown, No. | 0 | 0 | 1 | 0 | 1 | 0 | |||
Abbreviations: ASA, American Society of Anesthesiologists; BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); CCI, Charlson Comorbidity Index; DGCD, Danish Gynecological Cancer Database; FIGO, International Federation of Obstetrics and Gynecology; MIRS, minimally invasive robotic surgery; MIS, minimally invasive surgery; TAH, total abdominal hysterectomy.
a
Patients with missing values in noncrucial variables are included for transparency and sensitivity analyses. P values reflect comparison of patients without missing values.
b
Histopathologic risk is defined in the Categorization of Variables From the DGCD subsection of the Methods section.