Table 4.
The pooled associations between characteristic subgroups of miR-371––3 expression and prognosis of patients
| microRNA | Subgroup | Number of studies | Number of cases (High/low) |
HR (95% CI) | Heterogeneity (I2) | P-values |
|---|---|---|---|---|---|---|
| miR-372 | Total | 6 | 338/342 | 2.31 (1.04,5.14) | 87.9% | <0.001 |
| Race | ||||||
| Asian | 5 | 298/302 | 2.55 (0.90,7.25) | 90.2% | <0.001 | |
| Caucasian | 1 | 40/40 | 1.70 (1.00,2.89) | / | / | |
| Method | ||||||
| qRT-PCR | 5 | 305/255 | 2.94 (1.82,4.74) | 48.4% | 0.101 | |
| ISH | 1 | 33/87 | 0.53 (0.35,0.83) | / | / | |
| Cutoff | ||||||
| Median | 4 | 227/208 | 2.62 (1.54,4.46) | 45.3% | 0.139 | |
| Mean | 2 | 111/137 | 1.50 (0.19,11.74) | 95.8% | <0.001 | |
| miR-373 | Total | 6 | 316/322 | 0.68 (0.27,1.68) | 90.04% | <0.001 |
| Race | ||||||
| Asian | 5 | 269/276 | 0.51 (0.20, 1.31) | 89.8% | <0.001 | |
| Caucasian | 1 | 47/46 | 2.90 (1.27,6.63) | / | / | |
| Sample source | ||||||
| Tissue | 4 | 172/177 | 0.66 (0.24,1.79) | 88.9% | <0.001 | |
| Serum | 2 | 97/99 | 0.74 (0.05,10.57) | 95.9% | <0.001 | |
| Cutoff | ||||||
| NM | 3 | 170/173 | 0.78 (0.25,2.42) | 87.7% | <0.001 | |
| Median | 3 | 146/149 | 0.58 (0.27,1.69) | 94.4% | <0.001 |
Abbreviations: NM, not mentioned; qRT-PCR, quantitative real-time PCR; ISH, in situ hybridization.