Table 1. Multivariable Models for Skeletal Muscle Index, Muscle Area, and Muscle Radiodensity.
| Characteristic | Patients at Risk, No. | Events, No. | Model A | Model Ba | Model Cb |
|---|---|---|---|---|---|
| Age Adjusted, HR (95% CI) | Multivariable Without TAT, HR (95% CI) | Multivariable With TAT, HR (95% CI) | |||
| Sarcopenia (SMI < 40.0) | |||||
| Nonsarcopenic | 2155 | 365 | 1 [Reference] | 1 [Reference] | 1 [Reference] |
| Sarcopenic | 1086 | 254 | 1.25 (1.06-1.47) | 1.30 (1.10-1.54) | 1.41 (1.18-1.69) |
| SMI | |||||
| Continuously, per 1 SD (7.2) | 3241 | 619 | 0.96 (0.89-1.05) | 0.92 (0.85-1.00) | 0.87 (0.79-0.96) |
| Muscle area, cm2 | |||||
| Continuously, per 1 SD (19.9) | 3241 | 619 | 1.01 (0.93-1.10) | 0.95 (0.87-1.04) | 0.90 (0.82-0.99) |
| Muscle radiodensity (HU < 37.8) | |||||
| Normal radiodensity | 2048 | 355 | 1 [Reference] | 1 [Reference] | 1 [Reference] |
| Low radiodensity | 1193 | 264 | 1.08 (0.91-1.29) | 1.02 (0.85-1.22) | 0.95 (0.78-1.16) |
| Muscle radiodensity, HU | |||||
| Continuously, per 1 SD (9.7) | 3241 | 619 | 0.96 (0.87-1.05) | 0.98 (0.90-1.08) | 1.03 (0.93-1.15) |
Abbreviations: HU, Hounsfield units; SMI, skeletal muscle index; TAT, total adipose tissue.
a
Model B is adjusted for age at diagnosis (continuous), race (reference = white), stage (reference = II), grade (reference = Well), surgery type (reference = none), chemotherapy (reference = no), smoking (reference = never), estrogen receptor (reference = negative), human epidermal growth factor receptor 2 (reference = negative), and partitioned body mass index (continuous).
b
Model C adjusted for covariates in Model B plus total adiposity in cm2 (continuous).