Table 2. Multivariable Models for Total Adiposity and Sarcopenia.
| Characteristic | Patients at Risk, No. | Events, No. | Model A | Model Bb,c | Model Cd |
|---|---|---|---|---|---|
| Age Adjusted, HR (95% CI) | Multivariable Without Muscle, HR (95% CI) | Multivariable With Muscle, HR (95% CI) | |||
| BMIa at scan, categories | |||||
| Normal, 18.5 to <25 | 1163 | 199 | 1 [Reference] | 1 [Reference] | 1 [Reference] |
| Overweight, 25 to <30 | 1022 | 195 | 1.06 (0.87-1.29) | 0.96 (0.79-1.18) | 1.01 (0.82-1.24) |
| Obese, ≥30 | 1056 | 225 | 1.22 (1.00-1.48) | 1.10 (0.89-1.36) | 1.22 (0.96-1.55) |
| BMI at scan | |||||
| Continuously, per 1 SD (6.3) | 3241 | 619 | 1.08 (1.00-1.16) | 1.03 (0.94-1.13) | 1.10 (0.98-1.22) |
| Total adiposity, cm2 | |||||
| Low (tertile 1) | 1080 | 174 | 1 [Reference] | 1 [Reference] | 1 [Reference] |
| Middle (tertile 2) | 1081 | 214 | 1.21 (0.99-1.48) | 1.15 (0.94-1.41) | 1.21 (0.98-1.48) |
| High (tertile 3) | 1080 | 231 | 1.29 (1.05-1.57) | 1.22 (0.99-1.50) | 1.35 (1.08-1.69) |
| Total adiposity, cm2 | |||||
| Continuously, per 1 SD (20.0) | 3241 | 619 | 1.11 (1.03-1.20) | 1.07 (0.99-1.17) | 1.13 (1.03-1.24) |
| Sarcopenia and total adipositye | |||||
| Nonsarcopenic, low TAT | 537 | 66 | 1 [Reference] | 1 [Reference] | NA |
| Nonsarcopenic, mid TAT | 729 | 126 | 1.28 (0.95-1.73) | 1.22 (0.90-1.65) | NA |
| Nonsarcopenic, high TAT | 889 | 173 | 1.45 (1.08-1.94) | 1.40 (1.04-1.88) | NA |
| Sarcopenic, Low TAT | 543 | 108 | 1.35 (0.99-1.85) | 1.41 (1.03-1.92) | NA |
| Sarcopenic, Mid TAT | 352 | 88 | 1.83 (1.32-2.54) | 1.81 (1.30-2.52) | NA |
| Sarcopenic, High TAT | 191 | 58 | 2.05 (1.42-2.96) | 1.89 (1.30-2.73) | NA |
Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); Muscle, muscle area in cm2; NA, not applicable; TAT, Total adipose tissue.
BMI models do not include adjustment for partitioned BMI.
Model B is adjusted for age at diagnosis (continuous), race (reference = white), stage (reference = II), grade (reference = well differentiated), surgery type (reference = none), chemotherapy (reference = no), smoking (reference = never), estrogen receptor (reference = negative), human epidermal growth factor receptor 2 (reference = negative), and partitioned BMI (continuous).
The P value for interaction was .90.
Model C is adjusted for covariates in Model B, plus muscle area in cm2 (continuous).
Sarcopenia and total adiposity model is not additionally adjusted for muscle area.