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TUG1/miR-145/Sirt3/GDH regulatory network. (a) TUG1 can bind to miR-145 directly and inhibit its activity. (b) Sirt3, a positive regulator of GDH, is confirmed to be suppressed by miR-145. (c) GDH could reverse the inhibitive effect of glutamine metabolism caused by miR-145. (d) Knockdown TUG1 in ICC cell would lead to a dramatic decrease of glutamine consumption, indicating a positive glutamine metabolism regulation by TUG1.
