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Downregulation of MUS81 increases drug sensitivity to Olaparib. (A) Knockdown of MUS81 inhibited tumor growth in vivo. Injection of MUS81 downregulated A2780 cell lines. Xenografted tumor volume was measured every two days. *P < 0.05, shCtrl vs shMUS81-1.(B) The relative size of the tumor after administration. Representative images of xenografted tumors in the four groups.
