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. 2019 May 21;10(10):2261–2275. doi: 10.7150/jca.31077

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Mechanism diagram. SNORA71A was located at 20q11.23 and encoded from the third intron of SNHG17 under both endonucleases and exonucleases. In our study, knockdown of SNORA71A decreased the phosphorylation of MEK and ERK1/2. Knockdown of SNORA71A induced G1 phase arrest and suppressed proliferation of both A549 and PC9 cells. In addition, knockdown of SNORA71A decreased MMP2 and MMP9 levels and suppressed EMT, then inhibited cell invasion and migration. Furthermore, knockdown of SNORA71A suppressed xenograft tumor growth in mice.