Table 1.
Relative risk for cervical cancer development with specific DRB1and DQB1 allele exposure without consideration of HIV co-infection status.
| Relative Risk for pre-cancer | Relative Risk for cancer | ||||||
|---|---|---|---|---|---|---|---|
| HLA DRB1 | Cancer Allele frequency (2n=83) |
Pre-cancer Allele frequency (2n= 33) |
Healthy controls (Allele frequency) (2n=205) |
Odds ratio (95%CI) | P-value | Odds ratio (95%CI) | P-value |
| *01:01 | 0.024 (2) | 0.03 (1) | 0.024 (5) | 1.26(0.03-11.79) | 0.59 | 1(0.19-5.26) | >0.999 |
| *01:02 | 0.1 (8) | 0.121 (4) | 0.05 (11) | 2.45(0.5-9.0) | 0.135 | 1.91(0.6-5.4) | 0.193 |
| *03:01 | 0.072 (6) | 0.09 (3) | 0.073 (15) | 1.28(0.22-4.92) | 0.721 | 1(0.31-2.86) | >0.999 |
| *03:02 | 0.072 (6) | 0.15 (5) | 0.093 (19) | 1.8(0.47-5.43) | 0.345 | 0.77(0.24-2.12) | 0.817 |
| *04:01 | 0.036 (3) | 0 | 0.024 (5) | N/A | N/A | 1.52(0.23-8.01) | 0.693 |
| *04:04 | 0 | 0.09 (3) | 0.02 (4) | 5.07(0.7-31.3) | 0.057 | N/A | N/A |
| *04:05 | 0 | 0.03 (1) | 0.005 (1) | 6.42(0.08-506) | 0.257 | N/A | N/A |
| *07:01 | 0.084 (7) | 0.06 (2) | 0.07 (14) | 0.86(0.09-4.17) | >0.999 | 1.27(0.42-3.54) | 0.62 |
| *08:01 | 0.012 (1) | 0.03 (1) | 0.005 (1) | 6.4(0.1-506) | 0.257 | 2.5(0.03-198.7) | 0.491 |
| *08:04 | 0.012 (1) | 0.06 (2) | 0.04 (8) | 1.6(0.3-7.9) | 0.632 | 0.3(0.01-2.34) | 0.454 |
| *09:01 | 0.036 (3) | 0.03 (1) | 0.01 (2) | 3.2(0.1-62.6) | 0.361 | 3.86(0.43-46.75) | 0.143 |
| *10:01 | 0.06 (5) | 0 | 0.024 (5) | N/A | N/A | 2.6(0.58-11.6) | 0.155 |
| *11:01 | 0.1 (8) | 0.09 (3) | 0.112 (23) | 0.8(0.14-2.9) | >0.999 | 0.86(0.32-2.1) | 0.835 |
| *11:02 | 0.084 (7) | 0.03 (1) | 0.08 (16) | 0.37(0.01-2.6) | 0.48 | 1.1(0.37-2.98) | 0.813 |
| *11:04 | 0.024 (2) | 0 | 0.005 (1) | N/A | N/A | 5.1(0.26-302.5) | 0.197 |
| *12:01 | 0.036 (3) | 0.06 (2) | 0.024 (5) | 2.6(0.24-16.69) | 0.249 | 1.52(0.23-8.01) | 0.693 |
| *13:01 | 0.024 (2) | 0 | 0.122 (25) | N/A | N/A | 0.18(0.02-0.75) | 0.012 |
| *13:02 | 0.036 (3) | 0.09 (3) | 0.07 (14) | 1.4(0.2-5.3) | 0.713 | 0.5(0.1-1.9) | 0.411 |
| *13:03 | 0.072 (6) | 0 | 0.03 (7) | N/A | N/A | 2.2(0.6-7.9) | 0.208 |
| *14:01 | 0.024 (2) | 0 | 0.01 (2) | N/A | N/A | 2.5(0.18-35.45) | 0.323 |
| *15:01 | 0.05 (4) | 0.03 (1) | 0.024 (5) | 1.26(0.03-11.79) | 0.594 | 2.05(0.4-9.79) | 0.281 |
| *15:03 | 0.05 (4) | 0 | 0.083 (17) | N/A | N/A | 0.57(0.13-1.82) | 0.452 |
|
HLA DQB1 |
(2n=77) | (2n=31) | (2n=195) | ||||
| *02:01 | 0.078 (6) | 0.065 (2) | 0.092 (18) | 0.67(0.07-3.06) | >0.999 | 0.82(0.26-2.27) | 0.815 |
| *02:02 | 0.13 (10) | 0.032 (1) | 0.154 (30) | 0.18(0.03-1.19) | 0.09 | 0.81(0.33-1.82) | 0.706 |
| *03:01 | 0.169 (13) | 0.063 (2) | 0.04 (8) | 1.6(0.16-8.54) | 0.632 | 4.66(1.85-11.72) | 0.002 |
| *03:02 | 0.04 (3) | 0.063 (2) | 0.056 (11) | 1.1(0.12-5.42) | 0.696 | 0.67(0.12-2.6) | 0.763 |
| *03:19 | 0.013 (1) | 0 | 0.1 (20) | N/A | N/A | 0.11(0.003-0.74) | 0.011 |
| *04:02 | 0.1 (8) | 0.129 (4) | 0.067 (13) | 2.1(0.45-7.3) | 0.265 | 1.6(0.55-4.36) | 0.322 |
| *04:04 | 0 | 0 | 0.005 (1) | N/A | N/A | N/A | N/A |
| *05:01 | 0.065 (5) | 0.194 (6) | 0.113 (22) | 1.87(0.56-5.34) | 0.24 | 0.54(0.15-1.54) | 0.268 |
| *05:03 | 0.026 (2) | 0 | 0.05 (10) | N/A | N/A | 0.49(0.05-2.27) | 0.519 |
| *06:02 | 0.324 (25) | 0.29 (9) | 0.149 (29) | 2.3(0.85-5.81) | 0.07 | 2.68(1.45-4.96) | 0.002 |
| *06:03 | 0.013 (1) | 0.032 (1) | 0.072 (14) | 0.43(0.01-3.02) | 0.7 | 0.17(0.004-1.15) | 0.075 |
| *06:04 | 0.013 (1) | 0 | 0.077 (15) | N/A | N/A | 0.16(0.004-1.05) | *0.046 |
| *06:06 | 0 | 0.097 (3) | 0 | N/A | N/A | N/A | N/A |
| *06:09 | 0.026 (2) | 0.032 (1) | 0.02 (4) | 1.58(0.03-16.6) | 0.527 | 1.26(0.11-8.96) | >0.999 |
*The significant p-value was disregarded because the confidence interval crosses '1'