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. 2019 Jun 20;20(Suppl 12):314. doi: 10.1186/s12859-019-2833-2

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© The Author(s) 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Synthetic microbial frequency count distribution generated using NB distribution based on microbiome profiles. a The underlying true distribution which is highly zero inflated (i.e., no presence of certain microbe). b Type 1 error that adds non-zero noise to the zero count entries in order to change the distribution. c Type 2 error that changes the underlying non-zero entries to zeros. d Type 3 error changes the distribution of non-zeros counts. Note that all different types of errors are added with probability of 0.5