Figure 5.

FAM83D promotes activation of the oncogenic pathways. (A) The protein levels of FAM83D, EGFR, p‐EGFR and c‐Raf, p‐c‐Raf, ERK1/2, p‐ERK1/2, AKT and p‐AKT in the NM‐vector and NM‐FAM83D cells were quantified using Western blotting. (B) The protein levels of MMP2, N‐cadherin and ZO1 in the NM‐vector and NM‐FAM83D cells were quantified using Western blotting. (C) Schematic diagram summarizing the molecular mechanism through which FAM83D enhanced the proliferation and migration of ovarian cancer cells. EGFR, epidermal growth factor receptor, NM, non‐metastatic; MMP2, matrix metalloproteinase‐2