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. 2019 Jun 19;9:8823. doi: 10.1038/s41598-019-45243-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibition of the miRNA processing enzyme, DROSHA, enriches endometriotic lesion expression of pri-miR-144-3p but not pri-miR-451a. The endometriotic epithelial cell line, 12Z was transfected with either a non-targeting siRNA (NT; negative control) or DROSHA siRNA. Twenty-four and forty-eight hours after transfection, DROSHA mRNA (A) and protein (B) expression were determined as was pri-miR-144-3p (C) and pri-miR-451a (data not shown). Pri-miR-451a was not detected in any of the 12Z cell samples by qRT-PCR. Different letters indicate statistical significance (P < 0.01) among the means by one-way ANOVA followed by Bonferroni post-hoc analysis (planned comparisons).