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. 2019 May 21;23(7):4819–4828. doi: 10.1111/jcmm.14392

Figure 2.

Figure 2

Cutaneous signs are reduced in TRPA1 KO mice following 5 days of treatment with IMQ. (A) Representative images of the dorsal skin after IMQ treatment for 3 days (D3) and 5 days (D5). (B) PSI‐S, PSI‐E, PSI‐I, and total PSI scores in WT and TRPA1 KO mice after IMQ application for 3 days (D3) and 5 days (D5). (C) Fold change in skin thickness. (D) TEWL scores in the skin with IMQ treatment for 5 days. n = 12 in each vehicle group, n = 8‐20 in each IMQ group. PSI scores were assessed by Student’s T test; change in skin thickness and TEWL scores by two‐way ANOVA followed by Tukey's multiple comparisons test. Mean ± SEM values are indicated (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001). IMQ, imiquimod; KO, knockout; PSI, psoriasiform dermatitis; PSI‐S, PSI‐scaling; PSI‐E, PSI‐erythema; PSI‐I, PSI‐induration; TEWL, transepidermal water loss; TRPA1, Transient receptor potential ankyrin 1