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. 2019 Jun 19;9:8741. doi: 10.1038/s41598-019-45325-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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RG108 reduced anxiety-like behavior. (a) Time spent in the center of open field was significantly different between laser stimulated and sham cannula mice. RG108 injection increased the time spent in the open field of laser-stimulated mice. N = 5; p < 0.05. (b) The mobility measured by distance traveled during the open field test is not different between groups. N = 5; p > 0.05. (c) RG108 injected mice showed similar behavior in the elevated plus maze as the control mice. N = 5; p < 0.05.