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. 2019 Jun 19;9:8741. doi: 10.1038/s41598-019-45325-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Circuitry alterations of the RG108 treated mice were back to baseline levels comparable to non-stimulated WT mice. (a) PPR evaluated at 100-millisecond (msec) intervals. The PPR values were computed as the ratio of the second stimulus-evoked EPSC peak divided by the first stimulus-evoked EPSC peak. The PPRs of WT and laser stimulated WT DLS slices (WT saline: D1 N = 8, D2 N = 7; WT laser stimulated: D1 N = 8, D2 N = 7, RG108 injected D1 N = 8, D2 N = 9) were calculated from the averaged PPR values. p < 0.05. (b) Example traces of D1 recordings under control conditions, after laser stimulation and application of RG108. N = 9 D1s. (c) Relative NMDA/AMPA receptor contribution is elevated at BLA-D1 synapses in laser stimulated mice, and RG108 injection reverses the levels back comparable to controls. EPSCs evoked by full-field optogenetic stimulation in mice receiving stereotaxic ChR2 injections into BLA or sensorimotor cortex; NMDA/AMPA receptor-mediated synaptic contributions measured. N = 9 D1s and N = 9 D2s; p < 0.05. d Example traces of dSPN recordings under control conditions, after laser stimulation and application of RG108. N = 9 D1s.