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. 2019 Jun 19;9:8730. doi: 10.1038/s41598-019-45117-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Relationship between AUC2 and curve pattern of volume change (A) or beta value (B). (A) The six patterns of volume changes were follows: (1) reduction only but progressive disease due to nontarget lesions, (2) slow progression after rapid response, (3) rapid progression after rapid response, (4) slow progression after slight reduction, (5) rapid progression after slight reduction, and (6) sequential progression.