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. 2019 Jun 19;9:8771. doi: 10.1038/s41598-019-43998-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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miRNA seq analysis of samples reveal differentially expressed miRNA targeting AR and PGC1α. (A) List of miRNAs differentially expressed in G1 vs G4, G2 vs G4 and G3 vs G4 comparison. (B) Venn diagram of overlapping DE miRNA across groups. (C) Expression value of miR-138-5p and miR-615-5p across sample groups. Data represented as mean ± SD. *p < 0.05 in G4 compared to all other groups. (D) Summary IPA miRNA Target Filter analysis of DE genes from G1 vs G4 comparison superimposed onto experimentally verified and high-confidence targets reported for DE miRNAs. The most statistically significant canonical pathways were listed according to −log(p-value) of significance. Orange line represents ratio of genes in enriched pathway against number of genes in the input dataset.