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. 2019 Jun 19;10(7):484. doi: 10.1038/s41419-019-1714-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a FOXO3a was detected by western blot in the presence of 3-MA (4 mM) in A549 cells treated 15 μM LZ-101. b Annexin-V/PI staining assay by flow cytometry in the presence of 3-MA (4 mM) in A549 cells treated with 15 μM LZ-101. c ATG5 and ATG7 were detected by western blot after transfection of ATG5 or ATG7 siRNA into A549 cells. d Annexin-V/PI staining assay by flow cytometry in A549 cells treated with 15 μM LZ-101 and transfected ATG5 or ATG7 siRNA. Data are presented as mean ± SD. ^*P < 0.05, ^**P < 0.01 compared with DMSO group