Fig. 7. LZ-101 has a potential anti-tumor effect and low toxicity in vivo.

a Tumor volumes of control, 5-fluorouracil, LZ-101 treatment groups were measured and calculated every 3 days. b Weight of tumor in control, 5-fluorouracil, LZ-101 treatment groups. ^*P < 0.05, ^**P < 0.01 compared with control group. c DNA damage and FOXO3a, Bim, Bcl-2, Bax expression detected by TUNEL assay and immunohistochemistry in tumor xenograft tissues. Scale bars, 50 µm. d Nude mice weight was recorded every 3 days. e H&E stained main organs of mice from treated and control sets to evaluate the toxicity of LZ-101. Scale bars, 50 µm