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. 2019 Jun 19;5(6):eaav8062. doi: 10.1126/sciadv.aav8062

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Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 3 — Insulin fibrils obtained from 1:99 (A to C) and 1:499 (D to F) dye-to-protein ratios. AFM images (A and D), STED microscopy images (B and E), and correlative images (C and F). Several fibrils are totally unlabeled, while a homogeneous fluorescence is emitted by some other aggregates. The ratio of colocalization is shown by the histograms (C and F, insets). Scale bars, 2 μm.