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. 2019 Jun 19;9:8760. doi: 10.1038/s41598-019-45114-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Transmission electron micrographs of human liver of chronically HCV-infected patient. (a) Representative image of a preserved liver sinusoidal endothelium (E) and neighboring hepatocytes (H); a Kupffer cell (K) is visible into the sinusoidal lumen (asterisk). The inset shows intact cytoplasmic processes of sinusoidal endothelial cells with typical fenestrae (arrowheads). (b) The image show the sinusoidal lumen (asterisk) crowded by the presence of inflammatory cells and material originating from damaged cells. (c,d) Microvilli (arrowhead) extending from the surface of endothelial cells (E) and the presence of engulfed material (arrows) inside the cytoplasm are visible. Scale bars: a, b, c = 5 μm; d = 1.2 μm.