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. 2019 Jun 19;9:8760. doi: 10.1038/s41598-019-45114-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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EM analysis of sinusoidal modifications in HCV-infected liver. (a,b) Representative electron micrographs of capillarized LSECs. The absence of fenestrae and the development of a continuous lining (a) with the appearance of abnormal basement membrane (arrowheads) on the basal side of LSECs is shown. (c) The micrograph shows the swelling of sinusoidal endothelium (E), and the presence of large gaps (arrows). (d,e) Images show variable degrees of discontinuous endothelial lining leading shedding of hepatocytes vesicles (white arrow) into the sinusoidal lumen (asterisk) and to a widening of the space of Disse (Di). (f) Box Plot representing the distribution of capillarized and discontinuous LSECs according with fibrosis stage (Ishak scoring system) in HCV-infected liver. (H) hepatocytes; (*) sinusoidal lumen. Scale bars: a,e = 1.2 μm; b–d = 5 μm.