Table 2.
Macular (layer) thickness in ETDRS regions in AD and control participants
| Linear regression | ||||||||
|---|---|---|---|---|---|---|---|---|
| AD | Age | Sex | ||||||
| Retinal thickness measure | Alzheimer's disease (AD) | Controls | β | P value | β | P value | β | P value |
| Total retinal thickness (μm) | ||||||||
| Inner ring | 338.43 (±16.67) | 341.73 (±13.76) | −0.148 | .080 | −0.207 | .015 | 0.082 | .327 |
| Outer ring | 292.38 (±13.12) | 295.17 (±12.30) | −0.143 | .086 | −0.257 | .002 | −0.114 | .166 |
| Retinal nerve fiber layer (μm) | ||||||||
| Inner ring | 21.69 (±1.90) | 21.88 (±1.86) | −0.056 | .515 | 0.008 | .925 | 0.111 | .195 |
| Outer ring | 34.57 (±3.42) | 35.96 (±4.35) | −0.160 | .053 | −0.055 | .505 | −0.263 | .002 |
| Ganglion cell layer (μm) | ||||||||
| Inner ring | 49.71 (±4.66) | 50.15 (±4.58) | −0.110 | .170 | −0.382 | <.001 | 0.005 | .948 |
| Outer ring | 33.96 (±3.17) | 34.17 (±3.13) | −0.098 | .212 | −0.423 | <.001 | −0.053 | .495 |
| Inner plexiform layer (μm) | ||||||||
| Inner ring | 41.22 (±3.11) | 41.33 (±2.98) | −0.089 | .259 | −0.405 | <.001 | 0.073 | .351 |
| Outer ring | 28.35 (±2.53) | 28.33 (±2.12) | −0.051 | .530 | −0.347 | <.001 | −0.020 | .808 |
NOTE. Total retinal thickness, retinal nerve fiber layer thickness, ganglion cell layer thickness, and inner plexiform layer thickness in the fovea, inner ring (Ø 1-3 mm around the fovea) and outer ring (Ø 3–6 mm around the fovea) of the Early Treatment in Diabetes Retinopathy Study (ETDRS) grid in AD (n = 57) and controls (n = 85). Means (±SD), standardized β's, and uncorrected P values of linear regression models with retinal measures as dependent variables and diagnosis, age, and sex (male = 1, female = 0) as independent variables are shown. Significant findings after Bonferroni correction (0.05/8 = 0.006) are shown in bold.