Table 3.

Relationships between retinal measures and MRI visual rating scores and CSF biomarkers in the total cohort

A) Magnetic resonance imaging	GCA	PCA	MTA	Fazekas
Mean pRNFL
β	0.001	0.037	−0.111	0.001
P value	0.992	0.701	0.231	0.995
Perifoveal macular thickness
β	−0.314	−0.276	−0.204	−0.108
P value	0.001	0.003	0.028	0.298
B) Cerebrospinal fluid analysis	Aβ1-42	Tau-181	pTau	Tau/Aβ
Mean pRNFL
β	0.025	−0.028	0.013	0.027
P value	0.811	0.790	0.903	0.795
Perifoveal macular thickness
β	0.142	0.047	0.112	0.033
P value	0.178	0.660	0.296	0.756

NOTE. Linear regression models assessing relationships between mean pRNFL and perifoveal macular thickness (inner + outer ring) with visual rating scores on MRI (GCA, PCA, MTA, and Fazekas) and CSF biomarkers (Aβ_1–42, Tau_-181, pTau, and Tau/Aβ ratio) adjusted for age and sex (male = 1, female = 0) in the total cohort. Standardized β's and uncorrected P values are shown. Significant findings after Bonferroni correction (0.05/8 = 0.006) are shown in bold. MRI subgroup (n = 134) and CSF subgroup (n = 90).

Abbreviations: GCA, global cortical atrophy; MTA, medial temporal lobe atrophy; PCA, parietal cortical atrophy; pRNFL, peripapillary retinal nerve fiber layer; Aβ, amyloid β; AD, Alzheimer's disease; CSF, cerebrospinal fluid; MRI, magnetic resonance imaging; PET, positron emission tomography.