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. 2019 Jun 11;10:1305. doi: 10.3389/fimmu.2019.01305

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Copyright © 2019 Han, Ghaemi, Ando, Peterson, Ganio, Tsai, Gaudilliere, Stelzer, Einhaus, Bertrand, Stanley, Culos, Tanada, Hedou, Tsai, Fallahzadeh, Wong, Judy, Winn, Druzin, Blumenfeld, Hlatky, Quaintance, Gibbs, Carvalho, Shaw, Stevenson, Angst, Aghaeepour and Gaudilliere.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Model components reveals disrupted innate and adaptive immune cell dynamics in preeclampsia. Boxplots (left panels) depict the rate of change (ρ) of indicated immune feature for the eigth most informative model components. AUC and p-values are indicated on each graph (ROC analysis). Insets (right panels) depict immune feature values (arcsinh transform of the mass cytometry intracellular signal mean intensity) at individual time points (T1, T2) and for each patient. Color code: purple = controls, orange = preeclampsia.