Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jun 12;10:613. doi: 10.3389/fphar.2019.00613

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Bravo-Caparrós, Perazzoli, Yeste, Cikes, Baeyens, Cobos and Nieto

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Differential ability of Nx and NxM to reverse the effects of morphine on mechanical allodynia, heat hyperalgesia, and cold allodynia in female WT mice with SNI 7 days after surgery. Mechanical allodynia (A), heat hyperalgesia (B), and cold allodynia (C) were evaluated 1 day before (baseline, BL) and 7 days (day 7) after surgery in the paw ipsilateral to the surgery. On day 7 the responses to test stimuli were recorded immediately before (time 0) and at several times (30, 90, and 180 min) after injections of the drugs (morphine and opioid antagonists) or saline. Each point and vertical line represent the mean ± SEM of the values obtained in 8–14 animals. Statistically significant differences in comparison to the saline+morphine group: *P < 0.05; **P < 0.01 (two-way repeated-measures ANOVA followed by Bonferroni test).