Table 1. Comparison of the Main Properties, Advantages and Disadvantages of Commonly Used Viral Vectorsa.
vector type | packaging capacity | diameter | genome type | advantages | disadvantages | current examples |
---|---|---|---|---|---|---|
AAV | <4.4 kB | 20–22 nm | ssDNA | large variety of target tissues, low immunogenicity on first injection | low packaging capacity | (16) |
AV | >8 kB | 80–100 nm | dsDNA | large packaging capacity, transient Cas expression | pre-existing antibodies, high immunogenicity | (17) |
LV | <8.5 kB | 80–120 nm | ssRNA | large packaging capacity | potential insertional mutagenesis | (18−21) |
References of current examples are given for future reading.