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. 2019 Jun 2;10(12):2694–2705. doi: 10.7150/jca.31877

Figure 1.

Figure 1

Structure of the Slit/Robo protein family and their interaction. (A). Structure of the human Slit protein. Slits consist of five regions as follows: one N-terminal signal peptide, four leucine-rich domains (LRR, D1-D4) in tandem with disulfide bonds, six epidermal growth factor-like (EGF-like) domains, an Agrin-Perlecan-Laminin-Slit (ALPS)/Laminin-G-like domain, three epidermal growth factor-likedomains, and a C-terminal cysteine-rich knot. Slits are proteolytically cleaved between EGF-like domains. (B). Structure of the human Robo protein. The extracellular domains of the Robo1-3 proteins have the same structures, including 5 immunoglobulin domains, 3 fibronectin domains and one transmembrane domain. The Robo4 extracellular domain has only 2 immunoglobulin domains, 2 fiber connexin domains and one transmembrane region; the Robo1 and Robo2 intracellular region contains four conserved proline-rich domains, referred to as CC0-CC3. The Robo3 intracellular domain contains CC0, CC2 and CC3, and Robo4 only contains CC0 and CC2.